|
Depressive disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, very few studies have so far focused on the degree to which rare variants of SLC6A4 are responsible for the depression observed in adolescent and young adult suicide patients.
|
31629822 |
2020 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings did not reveal any major influence on SCZ and BPD development; On the other hand, some alteration of the SLC6A4 sequence were associated with an increased risk of ALC and ALZ disorders, suggesting common pathways.
|
31595439 |
2020 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, very few studies have so far focused on the degree to which rare variants of SLC6A4 are responsible for the depression observed in adolescent and young adult suicide patients.
|
31629822 |
2020 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
5-HTTLPR and <i>MTHFR 677C</i>>T polymorphisms and response to yoga-based lifestyle intervention in major depressive disorder: A randomized active-controlled trial.
|
30581206 |
2020 |
|
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Rare variants in SLC6A4 cause susceptibility to major depressive disorder with suicidal ideation in Han Chinese adolescents and young adults.
|
31629822 |
2020 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to examine the impact of common and rare variants of SLC6A4 on the risk of Han Chinese adolescents and young adults suffering MDD with SI.
|
31629822 |
2020 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
5-HTTLPR variant of the serotonin transporter gene (SLC6A4) and <i>MTHFR 677C</i>>T polymorphisms have been linked to the pathogenesis of MDD, and antidepressant treatment response.
|
30581206 |
2020 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several promising genes, such as the COMT (catechol-O-methyltransferase) gene, the serotonin transporter gene (SLC6A4), and neuropeptide Y (NPY) suggest gene × environment interaction between genetic variants, childhood adversity, and the occurrence of PTSD and MDD, indicating an impact of these genes on resilience.
|
31583809 |
2020 |
|
Cocaine Dependence
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
The data point to an important but differential role of the amygdala and dorsal raphe nucleus in 5-HTT genotype-dependent vulnerability to cocaine addiction.
|
30748070 |
2020 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings did not reveal any major influence on SCZ and BPD development; On the other hand, some alteration of the SLC6A4 sequence were associated with an increased risk of ALC and ALZ disorders, suggesting common pathways.
|
31595439 |
2020 |
|
Depressed mood
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
However, very few studies have so far focused on the degree to which rare variants of SLC6A4 are responsible for the depression observed in adolescent and young adult suicide patients.
|
31629822 |
2020 |
|
Substance abuse problem
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
While, there was no genetic association between the 5-HTTLPR (LL, LS, SS), rs25331 (AA, AG, GG) and tri-allelic (SASA, LASG, LASA, LALG, LALA) genotypes (P = 0.26, 0.71 and 0.52, respectively) and SUD.
|
31809838 |
2020 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings did not reveal any major influence on SCZ and BPD development; On the other hand, some alteration of the SLC6A4 sequence were associated with an increased risk of ALC and ALZ disorders, suggesting common pathways.
|
31595439 |
2020 |
|
Mental disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
SLC6A4 polymorphisms are not associated with the risk of developing major psychiatric disorders (SCZ and BPD); however some signals were detected in ALC (HTTLPR p<sub>d</sub> = 9.25 × 10<sup>-03</sup>, p<sub>r</sub> = 7.24 × 10<sup>-03</sup>; rs2066713 p<sub>d</sub> = 6.35 × 10<sup>-08</sup>; rs25531 p<sub>d</sub> = 2.95 × 10<sup>-02</sup>; rs4251417 p<sub>d</sub> = 2.46 × 10<sup>-03</sup>), and ALZ (rs6354 p<sub>r</sub> = 1.22 × 10<sup>-02</sup>; rs7224199 p<sub>d</sub> = 1.00 × 10<sup>-08</sup>, p<sub>r</sub> = 2.65 × 10<sup>-02</sup>) cohorts.
|
31595439 |
2020 |
|
Borderline Personality Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings did not reveal any major influence on SCZ and BPD development; On the other hand, some alteration of the SLC6A4 sequence were associated with an increased risk of ALC and ALZ disorders, suggesting common pathways.
|
31595439 |
2020 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Understanding the molecular regulation of placental SERT and 5-HT receptors using selective pharmacological agonists or antagonists may identify the therapeutic potential of serotonin pathway to improve long-term health outcomes of mothers and her infants exposed to GDM and obesity.
|
30738809 |
2020 |
|
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several promising genes, such as the COMT (catechol-O-methyltransferase) gene, the serotonin transporter gene (SLC6A4), and neuropeptide Y (NPY) suggest gene × environment interaction between genetic variants, childhood adversity, and the occurrence of PTSD and MDD, indicating an impact of these genes on resilience.
|
31583809 |
2020 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
SLC6A4 polymorphisms are not associated with the risk of developing major psychiatric disorders (SCZ and BPD); however some signals were detected in ALC (HTTLPR p<sub>d</sub> = 9.25 × 10<sup>-03</sup>, p<sub>r</sub> = 7.24 × 10<sup>-03</sup>; rs2066713 p<sub>d</sub> = 6.35 × 10<sup>-08</sup>; rs25531 p<sub>d</sub> = 2.95 × 10<sup>-02</sup>; rs4251417 p<sub>d</sub> = 2.46 × 10<sup>-03</sup>), and ALZ (rs6354 p<sub>r</sub> = 1.22 × 10<sup>-02</sup>; rs7224199 p<sub>d</sub> = 1.00 × 10<sup>-08</sup>, p<sub>r</sub> = 2.65 × 10<sup>-02</sup>) cohorts.
|
31595439 |
2020 |
|
Suicidal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that, consistent with the gene X environment (GXE) framework, an interaction between serotonin receptor (5-HTTLPR) gene and drug use would influence suicidal behaviors in BD patients.
|
31707246 |
2020 |
|
Huntington Disease
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
We tested this hypothesis in the scenario of Huntington disease (HD), a neurodegenerative disorder that is caused by the mutant HTT (mHTT) protein with an expanded polyglutamine (polyQ) stretch.
|
31690177 |
2020 |
|
Huntington Disease
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene that results in the production of neurotoxic mutant HTT (mHTT) protein.
|
31648394 |
2020 |
|
Neurodegenerative Disorders
|
0.070 |
GeneticVariation
|
group |
BEFREE |
We tested this hypothesis in the scenario of Huntington disease (HD), a neurodegenerative disorder that is caused by the mutant HTT (mHTT) protein with an expanded polyglutamine (polyQ) stretch.
|
31690177 |
2020 |
|
Neurodegenerative Disorders
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene that results in the production of neurotoxic mutant HTT (mHTT) protein.
|
31648394 |
2020 |
|
Bronchopulmonary Dysplasia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Our findings did not reveal any major influence on SCZ and BPD development; On the other hand, some alteration of the SLC6A4 sequence were associated with an increased risk of ALC and ALZ disorders, suggesting common pathways.
|
31595439 |
2020 |
|
Drug usage
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
We hypothesized that, consistent with the gene X environment (GXE) framework, an interaction between serotonin receptor (5-HTTLPR) gene and drug use would influence suicidal behaviors in BD patients.
|
31707246 |
2020 |